Anatomy

Aging in Cell and Tissue Culture: Proceedings of a symposium by E. Holeckova

By E. Holeckova

the once a year assembly of the ecu Tissue tradition ., Society was once held on the fortress of Zinkovy in Czechoslovakia from might 7-10,1969. integrated as a part of this assembly was once a symposium on "Aging in mobilephone and Tissue Culture." This quantity comprises the papers awarded at that symposium. using cellphone and tissue tradition options to check the mechanism of getting older isn't really new. for instance, it has lengthy been identified that age-associated alterations which happen in plasma can inhibit cellphone proliferation in vitro; additionally that the time lapse sooner than cellphone migration from ex­ planted tissue fragments raises with expanding age. those are either examples of the expression in vitro of getting older in vivo. extra lately, consciousness has been all in favour of the incidence of senescence in vitro. those investi­ gations have incorporated experiences of adjustments in non­ dividing mobile cultures, and to a a little bit higher quantity, of age-related adjustments within the proliferative skill of cells in vitro. for instance, cells derived from human fetal lung hold many houses of ordinary cells together with a strong common diploid karyotype and those cultures were proven to have a restricted life-span in vitro. In addi­ tion, cultures derived from human grownup lung exhibit an analogous general features and seem to have a shorter existence­ span than cells derived from fetal lung.

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