Medical Diseases

Advances in Osteoarthritis by Seisuke Tanaka,Chiaki Hamanishi

By Seisuke Tanaka,Chiaki Hamanishi

simple learn on osteoarthritis has been performed in most cases from the his­ tological and biochemical elements of the degenerating chondrocytes, collagen fibers, and matrix proteoglycans. Undue mechanical rigidity has been proven to be the primary think about the initiation of osteoarthritis. even if the precise method in which mechanical pressure results in the whole destruction of cartilage tissue is still uncertain, a number of new examine tools have enabled us to realize a deeper knowing of the method of degeneration. In October 1997, we equipped a world symposium titled "Ad­ vances in Osteoarthritis" in Kobe, with the most issues being up-to-date re­ seek, analysis, and remedy of osteoarthritis. The lawsuits of the symposium are awarded the following in 5 sections: (1) Mechanical pressure and reactions of chondrocytes, corresponding to intracellular ion alterations, alterations within the cytoskeleton, intracellular messenger platforms, liberate of gasoline mediators, and adjustments in electromechanical homes of cartilage; (2) practical prognosis of osteoarthritis by way of MR imaging, and utilizing calpain and collagenase III as new cartilage markers; (3) therapy with a promising uncomplicated washout method and IL-1RA and MMP antagonists; (4) Cartilage fix via new grafting tech­ niques; and (5) difficulties following overall joint substitute. We truly desire that the complex wisdom supplied during this quantity of lawsuits should be invaluable to our readers.

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